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Dapoxetine in usa was considered a breakthrough therapy for major depressive episode, and the first approved antidepressants in world. As for the clinical studies, these showed no improvement, and an increase in adverse events, despite an increase in clinical response. fact, the results weren't so good that the FDA stopped selling drug for depression, but took it off the market altogether — making drugs off-patent. The Food and Drug Administration's first official action on antidepressant drugs did not involve the drug fluoxetine. But, in fact, the agency went on to take a second look at antidepressant drugs, and this time took a dim view at many of the drugs. What did the FDA think of these drugs, and what led to the agency taking a dim view? The FDA's "Dimer" (Dime-Millions) Decision: decision, made in 1996, came with a huge blow to fluoxetine as a drug, and the first step of FDA's process to remove drug from the markets. The drug's generic counterpart, paroxetine (Paxil), was still available, so fluoxetine sales were down because of that. (It's not clear from the FDA's "Dimer" decision if paroxetine was the only antidepressant drug on market or just the first to be withdrawn over concerns about potential dangerous side effects.) Fluoxetine was also losing sales to its generic counterpart. In its "Dimer" decision, the FDA said that a few of these generics — specifically, ones made by Novartis and Eli Lilly — were more effective. The FDA also said that a few side effects were common among children and adolescents taking these drugs those who developed them did not improve with standard antidepressant treatments. But even though the FDA was concerned about efficacy of these drugs, the agency was concerned about Kamagra oral jelly c est quoi side effects. And the effects outweighed benefits on agency's review, so the FDA's concerns about fluoxetine were not resolved. They ignored, as this chart shows: A lot of the side effects in FDA's "Dimer" process included: Sleep problems — insomnia, sleeplessness, difficulty falling asleep, restless sleep. – insomnia, sleeplessness, difficulty falling asleep, restless sleep. Anxiety — nervousness, panic attacks, thoughts of death, restlessness, fear dying, thoughts that cannot be put into words. – nervousness, panic attacks, thoughts of death, restlessness, fear dying, thoughts that cannot be put into words. Depression — feelings of sadness, hopelessness, sadness and feelings of worthlessness, depression. – feelings of sadness, hopelessness, sadness and feelings of worthlessness,.




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